1、ONCln NHONH2NOHNH2NOHNH2NH3Backman rearrangement reactionDL-AminocaprolactamCH=CHCOOHCH2CHNH2COOHRCHCHRRCH2C*NH2HR加氨酶加氨酶CCOOHHRRCCOORHRRC*COOHHRRCCOOHHRRCOHRRCORC*OHHRRCCNHNH2RCCNHOHRCCO OHHNH2RCCO OHHOHR水解酶CORRC*OHRRHRROORROOHSCHCHCCH3OSCHCHCCH3OHNHNCH2CHCHONH2NHNCH2CHCH2OHNH2NHNCH2CHCHONH2ClNHCOON
2、NOHHClNHCOKetone derivative of inabenfide(s)-inabenfideAgonomycetales sp.yield:98%optical purity:ca 100%CH3AcOOCH3OOHCH3OAcOCH3OHOmicroorganism or enzymeONH2ROHOHH2O3POO*Conventional agar dilution method was employed using potato-sucrose medium.MICs were observed after 72 hours incubation.Tautomycet
3、inCH3OHCH3CH3CH3OOOOOHCH3OHOOOCH3The conventional agar diution method was used.Medium:potato sucrose agar.OOSNHONH2OHOHHOOCCOOHONHNHONHOOONH2ONH2NH*1（丁基氨基甲酰）（丁基氨基甲酰）2苯并咪唑苯并咪唑NHOONHNNHNHSNHNHNHNHOOOONHONHOHOOCOHOHCH3NHONHOOOOOCH3CH3ONHCH3ONHONOCH3NHOCH3CH3HHNHCH3OCH3OHCH3NHNHNR1R2OOCH3OHOHCH3OCH3OHOO
4、HOHOHCH3OHCH3OHOHOHOCOOHRS-22 A:R1=H,R2=HRS-22 B:R1=CH3,R2=HRS-22 C:R1=CH3,R2=CH3OHCH2OHOOHCH2OHOHOHOHNHOCH2OHOHOHOHOOOOOOOHCH3CH3HHHCH3OCH3CH3MeOMeOR4HHOR3HOHCH3HC2H5CH3OR4OOOOOOOOR2OCH3CH3CH3CH3R1R3ONOOOMeOMeOMeOHMeOMeMeOHOOHOOMeMeR123456789101112131415161718192021222324252627282930313233353436373
5、8394041424344OOHOHHNaOOCOHOHOOOHOOHHOOOHOOHHOOOHOOHHOCH3OHCH3OOOCH3OHOOOOHCH3CH3HOOCH3CH3HCH3CH3CHCNNH2RCHCNOHRCH2CHCNCHCNNH2RCHOHNH2CNCHCOOHNH2RCHCOOHOHRCHCNNH2RCH2CHCOOHCHOHNH2COOHNCNNCONH2NCNNCONH2NCNNCONH2NNCNNNCONH2SCNSCONH2OCONH2OCNNCH2CNNCH2CONH2RCHCNOHRCHCONH2OHRCHCOOHOHRCHCNNH2RCHCOOHNH2RCHCONH2NH2RCHCNCH3RCHCOOHCH3RCHCONH2CH3CH3CH3CNCH3CH3CONH2CHClCNCHClCONH2CHOHCNNH2CHOHCOOHNH2CHOHCNCHOHCOOHCNCONH2CNFFFFCONH2CNNH2NH2CONH2OHCNOHCONH2CNOCONH2OCNNO2CONH2NO2CH3CH3CH2CHCNCH2CHCNH2OCH2CHCONH2CH2CHCNCH2CHCONH2
